Clamping force has to exceed the force trying to push the two die halves apart during injection. That separating force is simply the projected area of everything on the parting plane multiplied by the pressure acting on it. Projected area means the shadow of the part, the runner, the biscuit and every overflow, not the part alone, and on a small casting the runner system can add 25 to 40% to the number.
Worked example. A gearbox cover measures 180 by 120 mm, giving 21,600 mm² of part projected area. Its runner, biscuit and overflows add roughly 27%, so total projected area is about 27,500 mm². The program calls for 70 MPa intensification pressure, so separating force is 27,500 mm² × 70 N/mm² = 1,925,000 N, or 196 tonnes. Adding a 25% margin for pressure spikes and die wear gives 245 tonnes required, so the part is scheduled on the 280 ton cell rather than the 400.
The margin matters. Running a die at 95% of rated clamping force produces flash on the parting line, drives the die apart at the far corners, and shortens tool life because the parting faces batter each other every shot. We size to roughly 75 to 80% of rated force and keep the remainder as headroom for the process window.